RNA sequencing of posterior fossa ependymoma harboring 6q loss

Two distinct groups of posterior fossa ependymoma, PF-EPN-A and PF-EPN-B have been identified in children and are often associated with widely distinct outcomes. We have identified an ultra-high-risk PF-EPN-A ependymoma with 6q loss. We performed RNA sequencing of posterior fossa ependymoma A (PF-EPN-A) tumor samples with chromosome 6q loss and balanced to understand the differences in 6q loss at the transcriptomic level Transcriptomic profiles of 10 ependymoma samples with chromosome 6q loss and balanced 6q status with 5 samples in each category