Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands

Asymmetric hydrogenation of unsaturated urea esters with the BIPI Ligands has been examined. Optimization of the P−N ligand structure has
led to the development of chiral rhodium catalysts capable of producing the targets with >99% ee. The critical phosphine borane SNAr reaction
needed for ligand synthesis has been optimized to give the adducts in high yield at ambient temperature with no racemization. An extremely
concise, economical, and scalable sequence to these important new ligands for catalysis of asymmetric hydrogenation has been developed.