KIT kinase domain in complex with a pyrrolotriazine-based compound (11)

KIT kinase domain in complex with a pyrrolotriazine-based compound (11) Descriptor: 6-(1-methylpyrazol-4-yl)-4-[4-[5-(phenylmethyl)pyrimidin-2-yl]piperazin-1-yl]pyrrolo[2,1-f][1,2,4]triazine, Mast/stem cell growth factor receptor Kit Authors: Scrima, A, Mueller, M.P, Rauh, D. Deposit date: 2025-11-27 Release date: 2026-07-15 Last modified: 2026-08-19 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. Nat Commun, 17, 2026