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Optimization of codon translation rates via tRNA modifications maintains proteome integrity

Alliance of Genome Resources2026-08-01 收录

翻译速率优化

tRNA修饰

数据链接：

https://www.yeastgenome.org/dataset/GSE67387 数据链接链接失效反馈

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Proteins begin to fold as they emerge from translating ribosomes

应用场景：

遗传密码子

tRNA修饰

Some codons of the genetic code can be read not only by cognate, but also by near-cognate tRNAs. This flexibility is thought to be conferred mainly by a mismatch between the third base of the codon an

NIAID Data Ecosystem50

Crystal structure of the covalent thioimide intermediate of the archaeosine synthase QueF-Like

结构生物学

tRNA修饰

Crystal structure of the covalent thioimide intermediate of the archaeosine synthase QueF-Like Descriptor: 2-amino-5-[(Z)-iminomethyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, Archeaosine synthas

Protein Data Bank Japan2024-11-06 更新20

Plant, Animal, and Fungal Micronutrient Queuosine Is Salvaged by Members of the DUF2419 Protein Family

tRNA修饰

营养素补救途径

Queuosine (Q) is a modification found at the wobble position of tRNAs with GUN anticodons. Although Q is present in most eukaryotes and bacteria, only bacteria can synthesize Q de novo. Eukaryotes acq

NIAID Data Ecosystem20

D-Tyr tRNATyr deacylase from Escherichia coli

酶功能研究

tRNA修饰

D-Tyr tRNATyr deacylase from Escherichia coli

NIAID Data Ecosystem20

DataSheet1_Impact of queuosine modification of endogenous E. coli tRNAs on sense codon reassignment.pdf

遗传密码扩展

tRNA修饰

The extent to which alteration of endogenous tRNA modifications may be exploited to improve genetic code expansion efforts has not been broadly investigated. Modifications of tRNAs are strongly conser

NIAID Data Ecosystem20

Optimization of codon translation rates via tRNA modifications maintains proteome integrity

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