RNA sequencing of NPM1cA/SMC+/- mouse myeloid sarcoma and whole bone marrow

This study was designed to investigate the RNA sequencing profile of mouse myeloid sarcomas in comparison to their matched whole bone marrow acute myeloid leukemia specimens. The goal was to determine gene set profiles that are different between the two phenotypes in the same primary genetic driver of AML mutation in mice to further investigate the results demonstrated in the patient derived specimens. Samples includes were mouse myeloid sarcomas (AML tumors) and mouse whole bone marrow specimens (infiltrated with AML). All but one pair were NPM1cA mutated in combination with heterozygous SMC3 (SMC3+/-) and one sample was NPM1cA mutated but wild type SMC3.