Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib

Protein Data Bank Japan2023-12-20 更新2026-03-21 收录

激酶靶向药物结构解析

ALK突变耐药机制研究

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Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib Descriptor: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, ALK TYROSINE KINASE RECEPTOR Authors: McTigue, M, Deng, Y, Liu, W, Brooun, A. Deposit date: 2012-03-22 Release date: 2013-03-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib To be Published

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2012-03-22

Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib

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