Oxoeicosanoid receptor can bind oxoeicosanoid

Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that are associated with cellular migration. These mediators are potent chemotaxins for eosinophils, monocytes and polymorphonuclear neutrophils. They act via the OXE receptor (Hosoi T et al, 2002), expressed principally in kidney, liver as well as in eosinophils, neutrophils, and lung macrophages. The most potent ligand is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Activation of the receptor leads to calcium mobilization and the receptor was shown to be coupled to the G alpha i subunit (Jones CE et al, 2003).

Oxoeicosanoids构成一类生物学活性化的花生四烯酸衍生物，与细胞迁移密切相关。此类介质对嗜酸性粒细胞、单核细胞和多形核中性粒细胞具有显著的趋化作用。它们通过OXE受体（Hosoi T et al, 2002）发挥作用，该受体主要表达于肾脏、肝脏以及嗜酸性粒细胞、中性粒细胞和肺巨噬细胞中。其中，最有效的配体为5-氧代-6,8,11,14-二十碳四烯酸（5-oxo-ETE）。受体的激活会导致钙离子动员，且研究表明该受体与G alpha i亚基相偶联（Jones CE et al, 2003）。