Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [Methylation array]

We generated genome-wide DNA methylation data from cultured airway epithelial cells exposed to rhinovirus (RV) and a vehicle control (48 hour treatment). This data was generated in combination with genome-wide expression data (RNAseq) and genotypes from the same individuals. Identification of DNA methylation quantitative trait loci (meQTLs) in vehicle- and RV-treated airway epithelial cells, and colocalization with childhood onset and adult onset GWASs.