Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [RNA-Seq]. Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [RNA-Seq]

共定位分析

We generated genome-wide gene expression data (RNAseq) from cultured airway epithelial cells exposed to rhinovirus (RV) and a vehicle control (48 hour treatment). This data was generated in combinatio

NIAID Data Ecosystem100

Epigenome-wide DNA methylation profiling in CBMCs. Epigenome-wide DNA methylation profiling in CBMCs

哮喘表观遗传学

DNA甲基化分析

To identify epigenetic mechanisms present at birth that underpin asthma development during childhood. Note - the Infant Immune Study cohort was only consented for asthma-related research. Overall desi

NIAID Data Ecosystem50

ChIP-seq of HBECs at ALI with and without stimulation of IFN-a, IL-17, and IL-13

哮喘表观遗传学

细胞信号通路

We used ChIP-seq to investigate epigenomic modifications in response to IFN-a, IL-17, and IL-13 in primary human bronchial epithelial cells (HBECs). Human HBE cells were treated with IL13, IL17 IFN al

NIAID Data Ecosystem30

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [Methylation array]

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Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [Methylation array]

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