GENOTYPIC AND PHENOTYPIC ASSESSMENT OF ANTIMICROBIAL RESISTANCE OF HELICOBACTER PYLORI: A MULTICENTRIC STUDY IN OMAN

Introduction: Antibiotic resistance is the leading cause of Helicobacter pylori infection therapy failure. Statistics on antibiotic resistance and genetic mechanisms of resistance are lacking in Oman, which is important for choosing the right medications to eradicate H. pylori. This study aims to investigate the antimicrobial resistance of clarithromycin, amoxicillin, levofloxacin, metronidazole, and tetracycline phenotypically in H. pylori. Moreover, this study focuses on the molecular characterization of multi-resistant isolates by Illumina whole genome sequencing.