Crystal structure of NRas-G12D in complex with GDP and compound 27

Crystal structure of NRas-G12D in complex with GDP and compound 27 Descriptor: (3P)-3-{3-[(1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl]-1-cyclopropyl-7-fluoro-4-(propan-2-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl}-5-chloro-4-(trifluoromethyl)aniline, CITRIC ACID, GTPase NRas, ... Authors: Johnson, T.A, Cross, J.B. Deposit date: 2025-08-31 Release date: 2026-02-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure-Guided Development of NRAS G12D Inhibitors Based on a 5‐Azaindole Core. Acs Med.Chem.Lett., 17, 2026