STING blockade reverses Alzheimer's pathology in microglia.
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https://www.ncbi.nlm.nih.gov/sra/SRP494400
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资源简介：
Abnormal glial activation accelerates Alzheimer's disease progression. Inhibiting STING activation controls microglia, alleviating AD symptoms. The cGAS-STING pathway detects ectopic DNA, triggering immune response. Amyloid beta and tau disrupt mitochondria, releasing DNA into microglial cytoplasm. STING is elevated in AD-related microglia, exacerbated by APOE epsilon 4 allele. STING activation drives microglial inflammation via NLRP3 and interferon responses. Pharmacological STING inhibition reduces AD pathology in mice, mitigating memory loss. In summary, targeting STING presents a promising therapeutic approach for AD.
创建时间：
2025-05-01
