Molecular data on the role of supramolecular assembly and function of the mitochondrial respiratory complexes in causing hypertension in stroke events

This dataset contains molecular research data on the role of mitochondrial dysfunction in increasing vulnerability to cerebrovascular disorders in hypertension in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive diet. When comparing SHR-SP strains to SHR-stroke resistant (SR) strains, the primary factor affecting the kinetic activity and SCs organisation of mitochondrial respiration is Complex I (CI) (dis)assembly in respiratory supercomplexes (SCs). In SHR-SP fed a high-salt diet, the arrangement of SCs and the leakage of substrate channelling in NADH oxidation CI-dependent were not observed under the same conditions in SHR-SR. Our findings demonstrate that the relationship of SCs with CI stability and dynamic protects against the manifestation of stroke.