Multi-omic comparison of Alzheimer’s variants in human ESC-derived microglia reveals convergence at APOE

NIAID Data Ecosystem2026-03-12 收录

阿尔茨海默病机制

干细胞多组学分析

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE153658 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2020-12-03

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

阿尔茨海默病机制

线粒体代谢

ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7

NIAID Data Ecosystem20

Table_1_Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF.DOC

阿尔茨海默病机制

针刺调控脑血流

BackgroundThe astrocytic phospholipase A2 (PLA2)-arachidonic acid (AA) pathway is crucial in understanding the reduction of cerebral blood flow (CBF) prior to cognitive deterioration. In complementary

NIAID Data Ecosystem10

Lysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction

阿尔茨海默病机制

溶酶体蛋白质组学

The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abn

NIAID Data Ecosystem00

AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons

阿尔茨海默病机制

BACE1转运与降解调控

Cleavage of amyloid precursor protein (APP) by BACE-1 (?-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-? (A?) production and a neuropathological hallmark of Alzheimer's disease (AD)

NIAID Data Ecosystem20

Data Sheet 1_Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model.docx

阿尔茨海默病机制

饮食诱导神经炎症

IntroductionWestern diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal white adipose tissue (eWAT), a representa

NIAID Data Ecosystem00

Multi-omic comparison of Alzheimer’s variants in human ESC-derived microglia reveals convergence at APOE

资源简介：

相关数据集