Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (RNA-Seq)

Investigation into changes in the methylome in young (2 months) and aged (22 months) Ames dwarf (Prop1 Hom) and WT (Prop1 Het) mice Overall design: We quantify transcription via high throughput RNA sequencing in young (2 months) and old (22 months) mice that show increased longevity through a variety of interventions