Module eigengene significance for co-expression modules.

The modules that were found by WGCNA in the first dataset are listed together with the number of genes they contain (shown in the second column). Differences in cases and controls were tested using a linear model with FDR correction. Results for the medicated cases versus controls are presented in column three and four. The modules that were found to be differentially expressed were also tested for significance between cases and controls in the antipsychotic-free set, and results are presented in the fifth and sixth column. The last column indicates the percentage of module content that was also found to be expressed in brain (log2>4). For all genes in the other modules, this was found to be 45%. For the Tan module, this was significantly higher (Fisher p = 4.3×10−4).