Effect of CYP3A4 polymorphism on citalopram metabolism

The original data file meticulously records the effects of CYP3A4 genetic polymorphisms on the metabolism of citalopram, including experimental results for CYP3A4 wild-type（CYP3A4*1） and 21 variants. Each data table presents the concentrations of the metabolite (demethylcitalopram) measured after incubating varying gradient concentrations of citalopram with CYP3A4 enzymes. This data is suitable for Michaelis-Menten kinetic analysis, enabling the calculation of relevant enzymatic kinetic parameters to assess the functional differences among the variants in citalopram metabolism.