PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass.

Supplementary Table 6. CRISPR screen raw sgRNA counts. Excel sheet 'Mellor et al Table S6_sgRNA_count.xlsx'. Output of the MAGeCK count command aligning Illumina sequencing reads to the sgRNA sequences within the Human Improved Genome-wide Knockout CRISPR library, following CRISPR/Cas9 screens in WT and primpol TK6 cells. Supplementary Table 7. CRISPR screen untreated summary. Excel sheet 'Mellor et al Table S7_untreated_summary.xlsx'. Output of the MAGeCK test command comparing sgRNA abundance between the sequencing libraries produced following a CRISPR/Cas9 knockout screen in WT versus primpol TK6 cells in untreated conditions. Supplementary Table 8. CRISPR screen cisplatin treated summary. Excel sheet 'Mellor et al Table S8_cddp_treated_summary.xlsx'. Output of the MAGeCK test command comparing sgRNA abundance between the sequencing libraries produced following a CRISPR/Cas9 knockout screen in WT versus primpol TK6 cells challenged with 7 days continuous 0.25 μM cisplatin treatment. readme.xlsx Tab 1: List of files Tab 2: Summary of CRISPR screen samples & conditions Raw sequencing data (zipped fastq files) WT_un_1.fastq.gz Wild type untreated replicate 1WT_un_2.fastq.gz Wild type untreated replicate 2WT_cis_1.fastq.gz Wild type cisplatin-treated replicate 1WT_cis_2.fastq.gz Wild type cisplatin-treated replicate 2Pp_un_1.fastq.gz primpol untreated replicate 1Pp_un_2.fastq.gz primpol untreated replicate 2Pp_cis_1.fastq.gz primpol cisplatin-treated replicate 1Pp_cis_2.fastq.gz primpol cisplatin-treated replicate 2