GS-4774 immunization inhibits growth of syngeneic, HBV-Ag expressing tumors in mice.

C57BL/6 mice (n = 8 per group) were thrice immunized and then challenged s.c. with syngeneic EL4 tumors expressing HBV antigens. Tumor diameters correspond to size at days 7, 8, 9, or 10 post-challenge. EL4/S-Core-Adoptive (day 7): data are from adoptive transfer of splenocytes from GS-4774- or Ovax-immunized mice to scid recipients prior to tumor challenge. “Mice with tumors”: fraction of mice with measureable tumors at the indicated day.*P-values: applicable to comparison of tumor diameters for GS-4774 vs. Ovax for each experiment (ANOVA).