Upon mitochondrial damage, TANK-binding kinase 1 (TBK1) is recruited to the damaged mitochondria through a direct interaction with the autophagy receptor optineurin (OPTN) (Heo JM et al., 2015; Richte
ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleic acid binding (inferred); INVOLVED IN activation of innate immune response (ortholog); defense resp
IRF3 is activated through a two-step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKKi, requiring Ser386 and/or Ser385- site 1; and a cluster of serine/threonine residues between S
