Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-75
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Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-75 Descriptor: 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-{[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]sulfonyl}-5'-deoxyadenosine, ... Authors: Shaw, G.X, Shi, G, Ji, X. Deposit date: 2020-10-09 Release date: 2020-12-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.488 Å) Cite: Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding. Bioorg.Med.Chem., 29, 2021
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2020-10-09
