Effect of cathodal and anodal iontophoresis of bosentan and sitaxentan on skin blood flux recorded on the back and the hind legs of rats during endothelin infusion.

Data are expressed as percentage change between baseline and iontophoresis plateau (%BL), and as the area under the curve (AUC0–20) of the percentage change from baseline (expressed as %BL.s), whether calculated from arbitrary perfusion units (PU) or from cutaneous vascular conductance (CVC) in order to take into account variations in arterial blood pressure.*vs NaCl (Wilcoxon rank test).P-values