RNA-sequencing of MHC-cycD2 transgenic mice after Transverse Aortic Constriction and Aortocaval Shunt surgery

Expression profiling by high throughput sequencing of mice overexpressing cyclin D2 compared to WT control, and of TG mice after pressure and volume overload Overall design: Examination of 4 Groups of mice: WT (n=5), MHC-cycD2 sham (n=5), MHC-cycD2 TAC (n=3), MHC-cycD2 Shunt (n=5) and 4 comparisons: GroupIcontrolWT_vs_GroupIicontrolsham, GroupIicontrolsham_vs_GroupIIITreatmentTAC, GroupIicontrolsham_vs_GroupIVTreatmentShunt, GroupIIITreatmentTAC_vs_GroupIVTreatmentShunt