Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation – Supplementary and Raw Data
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Supplementary and Raw Data for: "Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation" Dataset DOI: 10.5281/zenodo.17487466Date deposited: 2025-10-30 Manuscript DOI: 10.3390/antiox15020162Status: Online (https://www.mdpi.com/2076-3921/15/2/162) Contact: Emilio A. Herrera (eaherrera@uchile.cl) or Adolfo A. Paz (adolfopazf@gmail.com)Article: Antioxidants (MDPI) This study investigates the protective effects of prenatal melatonin administration on cardiovascular alterations induced by gestational hypoxia (GH) in newborn guinea pigs. Using a model of pregnant guinea pigs exposed to normoxia or hypoxia with or without melatonin treatment (1 mg/kg/day), this research evaluated neonatal outcomes through echocardiography, vascular reactivity tests, and molecular assays for oxidative stress and redox balance. Key findings include GH-induced reductions in birth weight, altered left ventricular development, enhanced systolic function, and impaired endothelial vasodilation, all partially reversed by melatonin. Melatonin also reduced oxidative stress and increased catalase activity in hypoxic neonates, though it unexpectedly modified cardiac structure in normoxic conditions.
