Changes in gene expression in inter-implantation sites by absence of Cbs

The change in gene expression on the 8th day of gestation was investigated using DNA microarrays. Uterine gene expression of interimplanted sites was analyzed in female mice. Female mice, C57BL/6jXOla129 genetic background were used for experiments. Mice, housed in sterile filter-top cages (3-4 per cage), were acclimatized in a room maintained at 24ºC with a 12-h light-dark fr four months. Two groups were established: a) The control group and b) homozygous Cbs deficient mice and sacrificed at the eight day post-coitum.