*All PXR simulations are based on 1ILG with residues 178–197 modeled in InsightII. **Single-site mutant of PPARγ generated in Pymol. There is no crystal structure of the mutant.
The use of computational modeling algorithms to guide the design of novel enzyme catalysts is a rapidly growing field. Force-field based methods have now been used to engineer both enzyme specificity
The flagellar motor/switch complex, consisting of the three proteins FliG, FliM, and FliN, plays a central role in bacterial motility and chemotaxis. We have analyzed FliG, using 10-amino-acid deletio