Stimulating effect of a new triterpene derived from Anoectochilus elwesii on glucose uptake in insulin-resistant human HepG2 cells

A new triterpene (1), 3-β-O-olean-11,13 (18)-diene-23,28-dioic acid, together with five known compounds (2–6), was isolated from Anoectochilus elwesii and their structures were elucidated by extensive spectroscopic methods and comparison with the literature data. Compound 1 was the first example of highly oxygenated triterpene obtained from Anoectochilus genus. The isolated compounds were evaluated on insulin-resistant human HepG2 cells for stimulating glucose uptake activity and the new compound displayed highly potent effect on the stimulation of glucose uptake in human HepG2 cells.