Project_02 Q47 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems

This study (Q47) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q47 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q47 was "Effect of 8OHDPAT dose (0 0.03125 0.0625 0.125 mg/kg) co-injected with a low dose of QNP (0.125 mg/kg) on the development of sensitization and compulsive checking (batch 2). Q47 was a repeat of Study Q46 (hence "batch 2" in title of experiment for Q47). For Q47, like for Q46 (dataset doi: 10.20383/102.0419), each rat received 13 trials in the open field. However, in IDStudy Q47, rats received a 14th trial in the open field, but for this test the open field was emptied of the 4 objects normally in it. This particular trial is grouped under Project_09 ("Probing the environmental modulation of sensitization and compulsive checking"), giving IDStudy Q47 a second title, "Probing the environmental modulation of sensitization and compulsive checking: influence of no objects in the open field on expression". The historical context for IDStudy Q47 includes the introduction of "enriched" housing, that is, a piece of black plastic tube was placed in the rat's home cage (prior to this study, there were no objects in the home cage). A comparison of study Q47 with Q46 showed that "enriched" housing did not influence the development of sensitization or compulsive checking