ProTherm

ProThermDB（Thermodynamic Database for Proteins and Mutants）是一个蛋白质及其突变体热力学数据库，由印度理工学院马德拉斯分校开发维护。该数据库收录蛋白稳定性相关的实验热力学参数（如熔解温度、自由能、焓变等），并结合序列、结构、实验条件及文献信息，支持蛋白质稳定性与突变效应研究。ProThermDB (Thermodynamic Database for Proteins and Mutants) is a thermodynamic database dedicated to proteins and their mutants, which is developed and maintained by the Indian Institute of Technology Madras. This database curates experimental thermodynamic parameters related to protein stability such as melting temperature, free energy, enthalpy change, etc., and integrates sequence, structure, experimental conditions and bibliographic information to support research on protein stability and the effects of mutations.

搜集汇总

背景与挑战

背景概述

ProThermDB是一个包含超过32,000条蛋白质和突变体热力学参数（如熔解温度、自由能）的数据库，涵盖多种实验方法和条件。它整合了约0.12百万条来自不同生物体和细胞系的数据，提供图形界面和搜索功能，并与PDB、UniProt等数据库交叉链接。