Kummer2000 - Oscillations in Calcium Signalling

Kummer2000 - Oscillations in Calcium
Signalling

Simplified (3-variable) calcium oscillation model Kummer et
al. (2000) Biophys. J. 79, 1188-1195 This model is defined in a
small compartment with low concentrations. You can run it first
with the LSODA ODE solver and then with the Gillespie Monte Carlo
method (in Time Course widget). This illustrates that at low
particle numbers, as here, the stochastic simulation and the ODE
approach produce different results (the stochastic approach is
more correct in these circumstances). This file also demonstrates
the use of several different plots to visualize results,
including a histogram.

This model is described in the article:

Switching from simple to
complex oscillations in calcium signaling.

Kummer U, Olsen LF, Dixon CJ, Green
AK, Bornberg-Bauer E, Baier G.
Biophys. J. 2000 Sep; 79(3):
1188-1195
Abstract:

We present a new model for calcium oscillations based on
experiments in hepatocytes. The model considers feedback
inhibition on the initial agonist receptor complex by calcium
and activated phospholipase C, as well as receptor
type-dependent self-enhanced behavior of the activated G(alpha)
subunit. It is able to show simple periodic oscillations and
periodic bursting, and it is the first model to display chaotic
bursting in response to agonist stimulations. Moreover, our
model offers a possible explanation for the differences in
dynamic behavior observed in response to different agonists in
hepatocytes.

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BioModels Database
and identified by:
BIOMD0000000329.
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the public domain worldwide. Please refer to
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