TNFalpha interferes with adaptation to starvation and activates pro-atherogenic processes

ChEBI2010-05-25 更新2026-07-21 收录

细胞应激反应

动脉粥样硬化机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-6423 数据链接链接失效反馈

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TNFalpha interferes with adaptation to starvation and activates pro-atherogenic processes

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2010-05-25

The influence of nt-LNA on cell composition and phenotypees in the atherosclerotic lesion.

动脉粥样硬化机制

单细胞RNA测序

Raw fastq files from paired-end, Illumina-based sequencing on NovaSeq6000 Apoe-/- mice were fed a western diet for 4 weeks and administered saline or nt-LNA (30 mg/kg) weekly. After 4 weeks, aortic a

NIAID Data Ecosystem80

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. doi: 10.1038/nm.4109

动脉粥样硬化机制

平滑肌细胞转录组

The multiple claims about reactivation of the embryonic stem cell (ESC) pluripotency factor OCT4 in somatic cells are highly controversial due to the fact that there is no direct evidence that OCT4 ha

NIAID Data Ecosystem70

Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells

动脉粥样硬化机制

泡沫细胞

Nicotinic acid (NA) regresses atherosclerosis in human imaging studies and reduces atherosclerosis in mice, mediated by myeloid cells, independent of lipoproteins. Since GPR109A is expressed by human

NIAID Data Ecosystem40

Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation

细胞应激反应

骨关节炎治疗靶点

The destruction of articular cartilage in osteoarthritis involves chondrocyte dysfunction and imbalanced extracellular matrix (ECM) homeostasis. Pro-inflammatory cytokines such as interleukin-1α (IL-1

NIAID Data Ecosystem80

KLF10 deficiency in CD4+ T cells promotes atherosclerosis progression by altering macrophage dynamics. KLF10 deficiency in CD4+ T cells promotes atherosclerosis progression by altering macrophage dynamics

动脉粥样硬化机制

免疫细胞互作网络

Gene expression profiling of aortic tissue from WT and CD4-KLF10-KO mice injected once with the AAV-PCSK9D377Y gain-of-function transgene and placed on high cholesterol diet. Overall design: 8 weeks o

NIAID Data Ecosystem60

TNFalpha interferes with adaptation to starvation and activates pro-atherogenic processes

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