Statistical analysis for all 14 inflammatory mediator levels in skin and in muscle at early postoperative time points (combined group of POD 3 and POD 5).

Most promising inflammatory mediators for classification of rejection, based on early identification before histological manifestation of rejection is evident, are selected (pKW<0.05 and Partition on DVs >1%, symbols in bold) and subjected to multinomial logistic regression analyses. For all measured inflammatory mediators adjusted p-values from Kruskal-Wallis test (KW) of overall equality between all 3 cohorts (ISO, TAC, ATC) and Wilcoxon rank-sum test (WR) for comparison between the rejection group (ATC) and the Tacrolimus treated group (TAC) as well as partition of each inflammatory mediator on the two discriminant vectors (DVs), which maximizes the separation between the 3 rejection groups, resulting from discriminant function analysis, are given.