ACAT2
收藏Figshare2025-07-25 更新2026-04-28 收录
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https://figshare.com/articles/dataset/ACAT2/29641151
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资源简介：
Phenotypic screening identified a site-specific (Y237) and regioselective SuPUR ligand of ACAT2 to reveal an unexpected metabolic dependency in cancer cells. A crystal structure of SuPUR ligand-bound ACAT2 revealed the purine group binds deep in the CoA pocket forming key interactions with catalytic residues via a water bridge to guide future structure-based ligand design.
创建时间：
2025-07-25
