Data_Sheet_1_Differential analysis of serum immunology and gut microbiota in patients with gastrointestinal diseases.ZIP

ObjectiveGastric and intestinal diseases possess distinct characteristics although they are interconnected. The primary objective of this study was to investigate the pathogenesis of gastrointestinal diseases through different analyses of clinical characteristics, serum immunology, and gut microbiota in patients with gastrointestinal diseases.MethodsWe collected serum samples from 89 patients with gastrointestinal diseases and 9 healthy controls for immunological assessment, stool samples for DNA extraction, library construction, sequencing, as well as clinical data for subsequent analysis.ResultsRegarding clinical characteristics, there were significant differences between the disease group and the healthy control (HC) group, particularly in terms of age, cancer antigen 125 (CA125), cancer antigen 199 (CA199), alpha-fetoprotein (AFP), total bilirubin (TBIL) and indirect bilirubin (IBIL). The intestinal disease (ID) group exhibited the highest IL-6 level, which significantly differed from the stomach disease (SD) group (p

本研究旨在探究胃肠道疾病的发病机制，通过对患者临床特征、血清免疫学以及肠道菌群的不同分析进行深入探讨。研究方法包括收集89例胃肠道疾病患者的血清样本和9例健康对照者的血清样本进行免疫学评估，收集粪便样本提取DNA，构建文库并进行测序，同时收集临床数据以供后续分析。研究结果在临床特征方面，疾病组与健康对照组在年龄、癌抗原125（CA125）、癌抗原199（CA199）、甲胎蛋白（AFP）、总胆红素（TBIL）和间接胆红素（IBIL）等方面存在显著差异。肠道疾病（ID）组中IL-6水平最高，与胃部疾病（SD）组存在显著差异（p