The gut metagenome of experimental autoimmune uveitis mice

This study aims to investigate the effect of PD-L1 knockout on gut microbiota in an experimental autoimmune uveitis (EAU) model. EAU was induced via immunization with interphotoreceptor retinoid-binding protein peptide 651-670 (IRBP651-670) in either wild-type or PD-L1 knockout C57BL/6J female mice. Sham adjuvant was administered to WT or PD-L1 KO mice as healthy controls. The characteristics of gut microbiota were analyzed using metagenomic sequencing.