Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

To investigate the effect of SARS-CoV-2 spike RBD on the transcription of nascent RNA in nerve cells, we treated SH-SY5Y cells with RBD and extracted nascent RNA for RNA-seq. We then performed gene expression profiling analysis using data obtained from RNA-seq of SH-SY5Y cells at two time points. Comparative analysis of gene expression profiles of RNA-seq data from SH-SY5Y cells treated with RBD at different time and its control group.