Metadate

We show that live attenuated <i>Salmonella enterica</i> Typhimurium mutants have antitumor potential <i>in vivo</i> against the aggressive melanoma model with no observable side effects. Intratumoral injection of attenuated <i>S. enterica</i> Typhimurium mediated the reduction of the tumor mass. Furthermore, we demonstrate that the tumor regression caused by our triple mutant is related to a shift to a pro-inflammatory response.