Values of five biophysical properties for individual drugs extracted from the 5 Hz train protocol.

Due to limitations in time resolution of our protocol, we assigned a value of 3s for carbamazepine (CBZ) and lidocaine (LID) whose onset time constants were too short to be resolved. On the other hand, lifarizine (LIF) and flunarizine (FLR) were completely irreversible within the duration of the protocol (200 s of washout); we assigned the value 500 s as the offset time constant of these drugs.
Abbr.:
aconcentration,
binhibition (inhibited fraction) at −90 mV holding potential using the 5 Hz train protocol,
creversibility,
duse-dependence of the inhibition,
edrugs not potent enough for further investigation.