Human transthyretin (TTR) gene expression is markedly increased in repair phenotype of hereditary ATTR Schwann cell model. Human transthyretin (TTR) gene expression is markedly increased in repair phenotype of hereditary ATTR Schwann cell model

TTR is markedly expressed in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal bovine serum (S-DMEM)-incubated TgS1 cells compared with Schwann cell medium (SCM)-incubated cells. c-Jun, Gdnf, and Sox2 were upregulated in S-DMEM-incubated TgS1 cell compared with SCM-incubated cells, while Mpz is suppressed in them. Overall design: Total RNA was isolated from SCM and S-DEMEM-incubated TgS1 cells. RNA sequence library preparation, sequencing, mapping, and gene expression analysis were performed.