To investigate the mechanism behind drug synergism between MLN8237 and venetoclax we injected DoHH2 human tumor cells into SCID mice SQ, treated animals for 3 days, and harvested tumors for RNAseq. Ov
In order to elucidate whether newly acquired genetic alterations during serial transplantation of patient derived primary pancreatic cancer cultures contribute to the observed clonal dynamics in vivo,
Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a
NOTE: mice were first scanned at the indicated age and then subjected to a series of sequential scans to monitor tumor growth. The slope of the growth curve was converted to tumor doubling time and gr
