Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion

mRNA and miRNA expression profiling shows that the T3 supplementation reverted the expression of 87 genes and 11 miRNAs that were dysregulated in the untreated group A rat model of myocardial IR, with or without an early short-term T3-replacement, was used to predict putative T3-dependent miRNA-gene interactions targeted to mitochondria quality control and wound healing repair. One Sham, two IR, and two IRT3 rats were collected for mirna profiling.