Discordant Grading Of Aortic Stenosis Severity: New Insights from an In Vitro Study

BACKGROUND: Low gradient (mean gradient, MG &lt; 40 mmHg) aortic stenosis (AS) may occur in conjunction with a small valve effective orifice area (EOA) &lt; 1 cm². This discordant grading in AS severity raises challenges from both a diagnostic and therapeutic standpoint. We sought to identify echocardiographic markers of severe AS in normal and low flow conditions <i>in vitro</i>. METHODS: In an <i>in vitro</i> mock circulatory system, we tested 6 degrees of AS severity (3 severe and 3 non-severe), and 3 levels of stroke volume (30, 50, 70 ml), heart rate (60, 80, 100 bpm), and mean arterial pressure (100, 120, 140 mmHg). MG and EOA were measured by Doppler-echocardiography. RESULTS: In normal flow conditions, a MG of 40 mmHg corresponded to an EOA of 0.85 cm², and an EOA of 1 cm² to a MG of 28 mmHg. The presence of EOA &lt; 0.85 cm² and MG between 24 and 40 mmHg in the low-flow condition yielded a 100% specificity for severe AS. In normal flow conditions, these thresholds were respectively &lt; 0.9 cm² and &gt; 36 mmHg. CONCLUSION: Low gradient AS may occur in severe AS in both low and normal flow conditions. The presence of a valve EOA &lt; 0.85 cm² with a mean gradient ≥ 25 mmHg may be used as a criteria to confirm the presence of severe AS in presence of low flow. In patients with normal-flow, a MG ≥ 37 mmHg is generally suggestive of severe AS.