Supporting data for “Fluoxetine treatment rewires vestibular circuitry and corrects deficits in egocentric navigation of adult mice”

The dataset ‘section 3.1.1’ contains all data quantified from mice subjected to negative geotaxis test used for generating result in section 3.1.1, including the identifier, treatment received (different doses of bicuculline via Elvax slice implantation and control) and the time taken to complete the test of each animal in each trial on each testing day.The dataset ‘section 3.1.2’ contains all data quantified from mice subjected to air-righting test used for generating result in section 3.1.2, including the identifier, treatment received (different doses of bicuculline via Elvax slice implantation and control) and the air-righting score of each animal in each trial on each testing day.The dataset ‘sections 3.1.3 and 3.1.4’ contains all data quantified from mice subjected to dead reckoning test used for generating result in sections 3.1.3 and 3.1.4, including the identifier, treatment received (different doses of bicuculline via Elvax slice implantation and control for section 3.1.3, treatment of fluoxetine and/or wobble vestibular stimulation after bicuculline via Elvax slice implantation for section 3.1.4) and the values for dead reckoning evaluation parameters of each animal in each trial.The dataset ‘section 3.2.2_P28’ contains all data quantified from the brain sections of P28 mice used in lineage tracing for generating result in sections 3.2.2, including the identifier, treatment received (fluoxetine treatment or control) and the values for each parameter of analysis (counts of different types of neural cells) from each animal.The dataset ‘section 3.2.2_P60’ contains all data quantified from the brain sections of P60 mice used in lineage tracing for generating result in sections 3.2.2, including the identifier, treatment received (fluoxetine treatment or control) and the values for each parameter of analysis (counts of different types of neural cells) from each animal.The dataset ‘section 3.2.3’ contains all data quantified from neurosphere assay using cells from P21 mouse brainstem for generating result in sections 3.2.3, including the number of cell clusters counted under different treatments (normal or with 5-HT supplement) with cells from dorsal brainstem or ventral brainstem in each trial.The dataset ‘section 3.3’ contains all data quantified from the brain sections of mice used in anterograde monosynaptic trans-neuronal tracing for generating result in sections 3.3, including the identifier, treatment received (control, bicuculline, or bicuculline with subsequent fluoxetine and wobble vestibular stimulation treatment) and the values for each parameter of analysis (cell counts) from each animal.The dataset ‘section 3.4’ contains all data quantified from the brain sections of mice used in retrograde monosynaptic trans-neuronal tracing for generating result in sections 3.4, including the identifier, treatment received (control, bicuculline, or bicuculline with subsequent fluoxetine and wobble vestibular stimulation treatment) and the values for each parameter of analysis (cell counts) from each animal.The dataset ‘section 3.5’ contains all data quantified from the brain sections of mice used in AAV-mediated retrograde tracing for generating result in sections 3.5, including the identifier, treatment received (control or bicuculline-treated) and the numbers of retrogradely labelled neurons in the medial vestibular nucleus from each animal.

数据集‘3.1.1节’收录了所有针对经负向地性测试处理的小鼠所量化得出的数据，旨在生成3.1.1节中的结果，包括标识符、所接受的治疗（通过Elvax切片植入的不同剂量比库库林和对照组）以及每只动物在每个试验日完成测试所需的时间。数据集‘3.1.2节’收录了所有针对经空气翻正测试处理的小鼠所量化得出的数据，旨在生成3.1.2节中的结果，包括标识符、所接受的治疗（通过Elvax切片植入的不同剂量比库库林和对照组）以及每只动物在每个试验日每个试验中的空气翻正评分。数据集‘3.1.3和3.1.4节’收录了所有针对经死地导航测试处理的小鼠所量化得出的数据，旨在生成3.1.3和3.1.4节中的结果，包括标识符、所接受的治疗（3.1.3节为通过Elvax切片植入的不同剂量比库库林和对照组，3.1.4节为比库库林通过Elvax切片植入后的氟西汀和/或摇摆前庭刺激治疗）以及每只动物在每个试验中的死地导航评估参数值。数据集‘3.2.2_P28’收录了用于生成3.2.2节结果的P28小鼠脑切片中所有量化数据，包括标识符、所接受的治疗（氟西汀治疗或对照组）以及来自每只动物的分析参数（不同类型神经细胞计数）的值。数据集‘3.2.2_P60’收录了用于生成3.2.2节结果的P60小鼠脑切片中所有量化数据，包括标识符、所接受的治疗（氟西汀治疗或对照组）以及来自每只动物的分析参数（不同类型神经细胞计数）的值。数据集‘3.2.3节’收录了使用P21小鼠脑干细胞进行的神经球实验中所有量化数据，旨在生成3.2.3节的结果，包括每个试验中不同处理（正常或添加5-HT补充剂）下细胞簇计数的数量，以及来自背侧脑干或腹侧脑干的细胞。数据集‘3.3节’收录了用于生成3.3节结果的，针对小鼠脑切片进行前向单突触跨神经元追踪实验的所有量化数据，包括标识符、所接受的治疗（对照组、比库库林、或比库库林随后接受氟西汀和摇摆前庭刺激治疗）以及每只动物的分析参数（细胞计数）的值。数据集‘3.4节’收录了用于生成3.4节结果的，针对小鼠脑切片进行逆向单突触跨神经元追踪实验的所有量化数据，包括标识符、所接受的治疗（对照组、比库库林、或比库库林随后接受氟西汀和摇摆前庭刺激治疗）以及每只动物的分析参数（细胞计数）的值。数据集‘3.5节’收录了用于生成3.5节结果的，针对小鼠脑切片进行AAV介导的逆向追踪实验的所有量化数据，包括标识符、所接受的治疗（对照组或比库库林处理组）以及每只动物内侧前庭核逆向标记神经元的数量。