Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs
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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs Descriptor: 2-(5-chlorothiophen-2-yl)-N-{(3S)-1-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-2-oxopyrrolidin-3-yl}ethanesulfonamide, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN Authors: Young, R.J, Borthwick, A.D, Brown, D, Burns-Kurtis, C.L, Campbell, M, Chan, C, Charbaut, M, Chung, C.W, Convery, M.A, Kelly, H.A, King, N.P, Kleanthous, S, Mason, A.M, Pateman, A.J, Patikis, A.N, Pinto, I.L, Pollard, D.R, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E. Deposit date: 2007-11-19 Release date: 2008-12-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs. Bioorg.Med.Chem.Lett., 18, 2008
创建时间：
2007-11-19
