Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 viruses with PB2 mammalian adaptations

Raw data from surveillance activities during the 2023 Highly Pathogenic Avian Influenza H5N1 outbreak in Chile.

Supplementary Table 1. Summary of HPAIV animal cases and samples according to host orders from December 05, 2022, to April 19, 2023, in Chile.

Supplementary Table 2. Summary of positive cases during the Chilean HPAIV H5N1 outbreak from December 05, 2022, to April 19, 2023.

Supplementary Table 3. Summary of sequencing results of the surveillance of H5N1 high pathogenicity avian influenza virus in Chile, December 05, 2022, to April 19, 2023.

Supplementary Table 4. Complete list of minor variant analysis of the Chilean HPAIV genomes according to allele frequency across all genome segments.

Supplementary Table 5. Summary of minor variant mutations analysis of the D701 Cluster sequences.

Supplementary Figure 1. Distribution of positive samples collected between December 1, 2022, and April 19st, 2023.

Supplementary Figure 2. Single introduction of HPAIV H5N1 clade 2.3.4.4b from North America into Peru and Chile.
Supplementary Figure 3. H5N1 Chile/Peru marine PB2 mammal clade.

Supplementary Figure 4. Phylogenetic clustering of H5N1 viruses with D701N PB2 mutation.

Supplementary Figure 5. Hypothetical tree topologies under three transmission scenarios.