Identification of a Resting Bold Connectome Associated with Cognitive Reserve - Data and code archive

The concept of cognitive reserve proposes that specific life experiences result in more flexible or resilient cognitive processing that allows some people to cope better than others with age- or disease-related brain changes. Imaging studies seeking to understand the neural implementation of cognitive reserve have most often used task-related fMRI studies. Using that approach, we recently described a task-invariant cognitive reserve network whose expression correlated with IQ and that moderated between cortical thickness and cognitive performance. Here we sought to identify a pattern of resting BOLD connectivity related to cognitive reserve. We identified a connectome pattern whose connectivity correlated with IQ both the derivation sample and a separate replication sample. The majority of the edges showing positive relationships with IQ implicate frontal regions. In the derivation sample, connectivity either moderated the relationship between mean cortical thickness and a set of cognit...