Purpose: The goal of this study is to investigate mesenchymal cell-type specific role of KLF4 in the context of lung fibrosis. Methods: Adult Pdgfrb-CreERT2, ROSA26R(Zs/+) mice were induced with tamox
Glucocorticoids remain the most widely used class of anti-inflammatory and immunosuppressive agents. They act primarily by binding to the glucocorticoid receptor, resulting in direct and indirect effe
The generation of blood cells in the hematopoietic microenvironment requires support from mesenchymal cells. We found that stably growing cell populations derived from individually sorted human bone m
Bleomycin-induced acute lung injury is characterized by mesenchymal cell activation, which leads to pulmonary fibrosis. They also have the potential to increase epithelial cells to regenerate alveolar
