Bridgehead-Substituted Triptycenes for Discovery of Nucleic Acid Junction Binders
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https://figshare.com/articles/dataset/Bridgehead_Substituted_Triptycenes_for_Discovery_of_Nucleic_Acid_Junction_Binders/3375382
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资源简介：
Recently, the utility
of triptycene as a scaffold for targeting
nucleic acid three-way junctions was demonstrated. A rapid, efficient
route for the synthesis of bridgehead-substituted triptycenes is reported,
in addition to solid-phase diversification to a new class of triptycene
peptides. The triptycene peptides were evaluated for binding to a
d(CAG)·(CTG) repeat DNA junction exhibiting potent affinities.
The bridgehead-substituted triptycenes provide new building blocks
for rapid access to diverse triptycene ligands with novel architectures.
创建时间：
2016-05-16
