Additional file 15 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
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Additional file 15. Table S9. Over-representation analysis (ORA) on downregulated genes in Cluster 1A compared to non-Cluster 1A tumours for Biological Process and Cellular Component gene ontology terms. Affected biological processes included inner dynein arm assembly (GO:0036159, ER=12.171, FDR=0.02), positive regulation of protein processing (GO:0010954, ER=7.86, FDR=0.03) and positive regulation of lipid biosynthetic process (GO:0046889, ER=4.4839, FDR=0.03). Some of the cellular components involved were collagen-containing extracellular matrix (GO:0062023, ER=3.4064, FDR < 0.001) and the neuronal cell body (GO:0043025, ER=3.1354, FDR=9.32 x 10-7).
提供机构:
Izatt, Louise; Oakey, Rebecca J.; Anastopoulos, Ioannis N.; Noberini, Roberta; Lim, Eugenie S.; Moonim, Mufaddal; Nathanson, Katherine L.; Hubbard, Johnathan G.; Obholzer, Rupert; Brempou, Dimitria; Tufton, Nicola; Chatzikyriakou, Prodromos; Fishbein, Lauren; Quinn, Mark; Bonaldi, Tiziana
创建时间:
2024-08-14



