Microfluidic platform for monitoring Saccharomyces cerevisiae mutation accumulation assay. Microfluidic platform for monitoring Saccharomyces cerevisiae mutation accumulation assay

Saccharomyces cerevisiae wildtype (YPH) and ung1-deleted strains were cultivated in mutation accumulation experiments over several bottlenecks (0-50-100-150). Two different cutlure systems were used either (i) using random colony selection and plating on petri dish (classical); or (ii) a microfluidic-based system (microfluidic)